Fecal Metabolomics and Gut Microbiota Profiling Uncover the Protective Role of Probiotic-Rich Traditional Fermented Sour Soup (Guizhou Hongsuantang) Against Alcoholic Liver Damage (opens in new tab)

ObjectiveThis study investigates the metabolic mechanisms underlying the hepatoprotective effects and mitigation of alcohol-induced impacts of bacterial strains (Lactobacillus plantarum LP and Lactobacillus paracasei H2) isolated from “Guizhou Hongsuantang.”MethodsIn order to identify changes in microbial composition, fecal metabolites and metabolic pathways linked to probiotic intervention, the study uses integrated gut microbiota analyses and metabolomics such as 16S rDNA sequencing, UHPLC-...