U-shaped relationship of plasma homocysteine with new-onset metabolic dysfunction-associated steatotic liver disease: a cohort study (opens in new tab)

ObjectiveMetabolic dysfunction-associated steatotic liver disease (MASLD) is defined by hepatic steatosis accompanied by metabolic abnormalities. Prior cross-sectional studies on the association between plasma homocysteine (Hcy) and MASLD, often limited by small sample sizes, have reported conflicting results.MethodsThis study included 5,184 adults from the Dalian Health Management Cohort (DHMC; 2014–2023), excluding those with baseline MASLD or severe comorbidities. MASLD was diagnosed using...