Targeting hepcidin to restore oral iron efficacy after vertical sleeve gastrectomy (opens in new tab)

BackgroundMetabolic bariatric surgery (MBS) such as Vertical Sleeve Gastrectomy (VSG) is the most effective intervention for obesity but commonly results in iron deficiency, inadequately managed by oral iron supplementation. This study aimed to investigate mechanisms underlying the inefficacy of oral iron supplementation post-VSG, evaluate clinical relevance through patient studies, and test the therapeutic potential of curcumin, a hepcidin inhibitor, to improve iron management.MethodsDiet-in...