The fatty liver index exhibits a dual association with chronic obstructive pulmonary disease: a machine learning-based analysis of two independent cohorts (opens in new tab)

BackgroundChronic obstructive pulmonary disease (COPD) and non-alcoholic fatty liver disease share common metabolic and inflammatory pathways. This study aims to elucidate the dual association of the fatty liver index (FLI) with COPD.MethodsA dual-cohort study was conducted using data from the National Health and Nutrition Examination Survey (NHANES) 2017–2020 (n = 15,560) and a clinical cohort from the Wenzhou Third Affiliated Hospital, China (n = 296). Feature selection was performed using ...