Joint association of estimated skeletal muscle mass index and prognostic nutritional index with all-cause mortality in individuals with non-metastatic nasopharyngeal cancer (opens in new tab)

BackgroundThe prognostic interplay between skeletal muscle mass and nutritional/immune status in non-metastatic nasopharyngeal carcinoma (NPC) is unclear. This study investigates the independent and joint association of estimated skeletal muscle mass index (eSMI) and Prognostic Nutritional Index (PNI) with all-cause mortality.MethodsWe analyzed 942 non-metastatic NPC patients. Low muscle mass was defined by sex-specific 20th percentiles of eSMI. PNI was categorized using a clinical cutoff of ...