Nutritional supplementation remodels yak cardiac molecular networks through selenoprotein activation and immune quiescence (opens in new tab)

Seasonal nutritional stress during prolonged winters represents a pivotal yet understudied environmental determinant constraining livestock productivity on the Qinghai-Tibet Plateau. While cardiac adaptive mechanisms to chronic hypoxia have been extensively characterized in high-altitude ungulates, the molecular architecture underlying myocardial responses to nutritional perturbation remains largely unexplored. Here, we present the first integrative transcriptomic-proteomic atlas of yak cardi...