Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults (opens in new tab)

Aging is closely associated with oxidative stress, mitochondrial dysfunction, chronic inflammation, and progressive declines in muscle and cognitive function. Exercise is widely recognized as the most effective non-pharmacological strategy to counteract these processes; however, its benefits may be potentiated by targeted nutritional interventions. Glycine and N-acetylcysteine (NAC), both precursors of the antioxidant glutathione, have emerged as promising candidates for maintaining redox bal...