Nutritional timing and stress biology: intermittent fasting as a hormetic signal for adaptation (opens in new tab)

Intermittent fasting (IF) and time-restricted eating (TRE) are recognized as metabolic interventions that link energy balance regulation with influence on stress-related physiological and neuroendocrine processes. Accumulating evidence suggests that IF acts as a mild, controllable stressor that triggers adaptive cellular and systemic responses. Central mechanisms that are involved in these effects are nutrient-sensing pathways, including AMP-activated protein kinase, sirtuins, the target of r...