Megestrol acetate in the management of cancer cachexia: a prospective quasi-experimental study focusing on body composition and patient-reported outcomes (opens in new tab)

BackgroundThe objective of this study is to investigate the efficacy of megestrol acetate (MA) in treating cancer cachexia from multiple dimensions.MethodsIn this prospective, non-randomized study, 97 patients with cancer cachexia were allocated to either a control group (n = 33, regular diet) or an MA group (n = 64, regular diet plus MA 320 mg/day) for 2 months. The primary endpoints were nutritional indices, including weight, BMI, total skeletal muscle mass, and fat mass. Secondary endpoint...