Identification of shared biomarkers in obesity and non-alcoholic fatty liver disease: a comprehensive analysis of Mendelian randomization and transcriptomic dat... (opens in new tab)

IntroductionObesity and non-alcoholic fatty liver disease (NAFLD) are known to be closely interlinked; however, the mechanism of their interaction is unclear. This study sought to explore the causal relationship and shared biomarkers in obesity and NAFLD by combining Mendelian randomization (MR) and transcriptomic data.MethodsA bidirectional MR analysis was performed using summary statistics data from GWAS database to determine the causal relationship between obesity and NAFLD. Based on trans...