The association between red blood cell distribution width-to-albumin ratio and Helicobacter pylori seropositivity in U.S. adults: an observational study from NHANES 1999-2000 with external validation (opens in new tab)

ObjectivesHelicobacter pylori (Hp) seropositivity, linked to inflammatory morbidity, may reflect host inflammation-nutrition imbalance. The red blood cell distribution width-to-albumin ratio (RAR) has been proposed as a composite marker reflecting this axis. Using NHANES data and an external validation cohort of 250 hospital patients, we aimed to examine the association between RAR and H. pylori seropositivity.MethodsThis study included U.S. adults from NHANES 1999–2000 and an external valida...