Does creatine affect lipid profile? a systematic review and meta-analysis of randomized placebo-controlled trials (opens in new tab)

IntroductionCreatine, recognized for its regulatory functions in various metabolic tissues, has aroused interest regarding its systemic effects. This study aimed to evaluate the impact of creatine supplementation on blood lipid profile parameters.MethodsA systematic review with meta-analysis was conducted following the PRISMA guidelines (CRD420251025690). Searches were conducted in EMBASE, Lilacs, CINAHL, MEDLINE/PubMed, Cochrane, Scopus, and Web of Science databases up to June 2025. Randomiz...