High-protein supplementation in critically ill patients: a systematic review, meta-analysis and umbrella review of existing evidence (opens in new tab)

BackgroundProtein serves as a core component of nutritional support for critically ill patients; however, no unified consensus or clinical standard has been established for protein supplementation to date. This gap highlights the urgent need for an updated systematic review and meta-analysis.MethodsRandomized controlled trials (RCTs) and meta-analyses that met our criteria were included in PubMed, Web of Science, Cochrane Library and Embase English databases up to April 1, 2026. We used meta-...