Secretor status-dependent modulation of in vitro immune responses by human milk oligosaccharides (opens in new tab)

IntroductionHuman milk oligosaccharides (HMOs) are structurally diverse carbohydrates found in high concentrations in human milk, supporting infant immune development and gut microbiota colonization. Their composition is influenced by maternal Secretor (Se) status, determined by the FUT2 gene. While immunological HMO effects are increasingly recognized, the influence of an infant’s own Se status on immune responses remains understudied. This study explores how peripheral blood mononuclear cel...