Regulation of bile acids homeostasis: a feasible and versatile way to treat or diagnose liver disorders (opens in new tab)

Homeostatic imbalance of bile acids (BAs) is closely associated with the onset and progression of several liver diseases, including cholestasis, hepatic fibrosis, cirrhosis, hepatocellular carcinoma, and MASLD/MASH. In cholestasis, BAs imbalance induces cellular endoplasmic reticulum stress and mitochondrial dysfunction, which subsequently lead to hepatocellular and cholangiocellular death, exacerbating liver injury. Bile acid imbalance also activates hepatic stellate cells, promoting fibrosi...