Therapeutic potential of modulating endogenous PYY expression for controlling overweight and obesity: a narrative review (opens in new tab)

Endogenous peptide YY (PYY) plays a pivotal role in the regulation of appetite and body weight, and the upregulation of its expression provides a novel strategy for obesity intervention. This review systematically elaborates on the physiological functions of PYY, its secretory mechanisms, and the potential for promoting endogenous expression through multiple approaches. PYY is primarily secreted by intestinal L-cell. By activating NPY2R in the hypothalamic arcuate nucleus, it modulates the PO...