Perinatal phlorizin alleviates maternal high-fat diet-induced metabolic syndrome in female mouse offspring and is associated with modulation of the gut microbio... (opens in new tab)

IntroductionMaternal obesity induces transgenerational metabolic syndrome (MS). The role of phlorizin (PHZ) in improving MS has been confirmed; however, the transgenerational metabolic benefits of PHZ in female offspring remain unclear. This study aimed to investigate whether perinatal PHZ intake could mitigate the adverse metabolic effects of maternal high-fat diet (HFD) in female offspring and to elucidate the role of the gut microbiota in mediating these transgenerational effects.MethodsC5...