Causal interplay between lactose intolerance and gut microbiota: a combined bidirectional Mendelian randomization and in vivo validation study (opens in new tab)

ObjectivesThe causal relationship between gut microbiota and lactose intolerance (LI) remains elusive due to confounding factors in observational studies. This study aims to decipher the bidirectional causal link between specific gut bacterial taxa and LI by integrating genetic inference with experimental validation.MethodsWe employed a two-sample bidirectional Mendelian Randomization (MR) analysis using summary statistics from the MiBioGen Consortium (gut microbiota) and the FinnGen study (L...