Sarcopenia and satellite cell homeostasis disruption: the dual function of NAD+ metabolism (opens in new tab)

Sarcopenia is an age-related syndrome characterized by progressive loss of skeletal muscle mass and function, which is closely associated with impaired regenerative capacity of muscle satellite cells (MuSCs). During aging, the MuSC niche undergoes severe deterioration, including mitochondrial dysfunction, chronic inflammation, and neuromuscular junction (NMJ) degeneration, all of which compromise MuSC quiescence, proliferation, and differentiation.Nicotinamide adenine dinucleotide (NAD+) serv...