Rhodomyrtus tomentosa fruit ameliorates LPS induced depression-like behaviors in mice by attenuating hippocampal neuroinflammation via inhibiting the TLR4/MyD88/MAPK/NF-κB/NLRP3 signaling pathway (opens in new tab)

IntroductionRhodomyrtus tomentosa fruit is a dietary food with various bioactivities. However, the comprehensive mechanisms underlying its antidepressant effects remain be fully understood.MethodsThis study aimed to assess the effects of the ethanol extract from R. tomentosa (RTEE) on depression-like behaviors in lipopolysaccharide (LPS)-challenged mice, and to explore the molecular basis.ResultsThe results showed that RTEE significantly improved LPS induced depression-like behaviors in mice,...