Nutritional properties of extracellular vesicle-like particles from Sophora flavescens and Periplaneta americana with effects on streptozotocin-induced diabetic wound healing in rats (opens in new tab)

IntroductionThe medicinal plant Sophora flavescens (SF) and the insect Periplaneta americana (PA) have long been used in treating diabetic wounds. PA-derived extracellular vesicle-like particles (PA-EVLP) can accelerate diabetic wound healing. However, no evidence of the nutritional components and anti-diabetic wound effects of the combination of SF-EVLP with PA-EVLP (SF-PA-EVLPs) is available.MethodsWe separated SF-EVLP and PA-EVLP via ultracentrifugation and characterized them via nano flow...