Enhancement of intestinal barrier function and alleviation of mycophenolic acid toxicity by a probiotic-conditioned medium in vitro (opens in new tab)

Immunosuppressant drugs may damage the intestinal barrier (IB) either indirectly by promoting dysbiosis, or directly by cytotoxic effects exerted on intestinal cells. This has been demonstrated, for instance, with the inosine monophosphate inhibitor mycophenolic acid (MPA) and with its ester prodrug mycophenolate mofetil (MMF). These two drugs can cause severe gastrointestinal toxicity in transplant patients receiving them for rejection prophylaxis. We investigated whether a multistrain probi...