Balancing metabolic optimization and reproductive safety in Polycystic Ovary Syndrome: a Bayesian-informed framework for GLP-1 receptor agonists (opens in new tab)

BackgroundGLP-1 receptor agonists (GLP-1RAs) address key metabolic drivers of Polycystic Ovary Syndrome (PCOS), yet their integration into fertility management remains challenging because reproductive efficacy is variably reported, preconception washout is required, and standardized clinical pathways are lacking.Main bodyWe present a structured, fertility-centered, hypothesis-generating narrative synthesis of the metabolic–reproductive–pregnancy continuum in PCOS, integrating evidence from ra...