Nutritional risk and cancer pain as determinants of radiotherapy-induced severe lymphocytopenia: development and validation of a nutrition-integrated predictive nomogram (opens in new tab)

BackgroundRadiotherapy-induced severe lymphocytopenia (SL) represents a critical immune-related toxicity associated with poor oncologic outcomes. While treatment-related factors have been extensively studied, the contribution of baseline nutritional risk and cancer-related pain to immune vulnerability during radiotherapy remains insufficiently explored. This study aimed to evaluate the role of nutrition- and symptom-related factors in SL and develop a clinically applicable predictive model.Me...