Association of SPISE with prevalent and incident MASLD: a two-stage population-based study and development of a risk prediction model (opens in new tab)

BackgroundThe prevalence of metabolic dysfunction–associated steatotic liver disease (MASLD) is increasing, and the disease is often asymptomatic in its early stages. Insulin resistance is central, but fasting-insulin–based indices are impractical for routine screening. The single-point insulin sensitivity estimator (SPISE) is simple and inexpensive, but its longitudinal association with MASLD and predictive utility remain unclear.MethodsA two-stage study was performed. Cross-sectional analys...