Bioavailable human metabolites of a keratin-derived hydrolysate promote primary human dermal fibroblast activities and protect against oxidative stress-related damages (opens in new tab)

IntroductionNutricosmetic strategies may support skin homeostasis by modulating dermal fibroblast function. Poultry feather keratin hydrolysates are a sustainable source of amino acids and low–molecular weight peptides. We investigated whether bioavailable human metabolites generated after ingestion of a keratin-derived hydrolysate (Kera‑Diet®) influence primary human dermal fibroblasts and protect against oxidative stress–related damage.MethodsTen healthy fasted men ingested 5,000 mg Kera‑Di...