Sinensetin ameliorates established high-fat diet-induced liver injury and intestinal barrier dysfunction through the mitophagy/TLR4/MAPK signaling pathway (opens in new tab)

IntroductionLong-term consumption of a high-fat diet (HFD) causes liver injury characterized by steatosis, inflammation, and fibrosis. Mitophagy, as a selective autophagy, is reported to be involved in the regulation of liver injury. Sinensetin, a polymethoxylated flavonoid abundant in citrus fruit peels, exhibits various biological activities, including anti-inflammatory and hepatoprotective properties. However, whether sinensetin can target mitophagy and protect against HFD-induced liver da...