Exploring the bioavailability and bioactivity of thiamine versus allithiamine: studies in Drosophila melanogaster and mice (opens in new tab)

ObjectiveThiamine (vitamin B1) is an essential micronutrient involved in carbohydrate metabolism and mitochondrial function. Allithiamine, a lipid-soluble thiamine derivative, has been proposed to exhibit thiamine bioactivity.MethodsHere, we conducted complementary studies in Drosophila melanogaster and laboratory mice to compare the bioavailability and bioactivity of thiamine and allithiamine. First Drosophila was established as a whole-organism model to assess thiamine activity. Flies were ...