Intermittent fasting alleviates irradiation-induced neuronal mitochondrial damage in mice (opens in new tab)

PurposesRadiation-induced brain injury (RIBI) is a common side effect of cranial radiotherapy. Intermittent fasting (IF) decreases the risk of Brain aging disease by affecting mitochondrial function. We examined the effects of IF on mitochondrial function, neurogenesis, morphology of hippocampal neurons and cognitive abilities in a whole-brain radiotherapy (WBRT) mouse model.Methods6–8 weeks old male C57BL/6J mice received 10 Gy WBRT. IF group mice were subjected to cycles of 24 h food restri...