HALP, a routine nutrition-inflammation index, and mortality across the cMetS spectrum: NHANES with supportive external cohort evidence (opens in new tab)

BackgroundThe continuous metabolic syndrome score (cMetS) quantifies cardiometabolic burden but may not fully capture systemic vulnerability related to nutrition, immunity, and thrombo-inflammation. We examined the prognostic value of the hemoglobin-albumin-lymphocyte-platelet (HALP) index across the cMetS spectrum.MethodsAdults aged ≧ 20 years from NHANES 1999–2010 were followed through 31 December 2019. HALP was assessed using survey-weighted Cox regression with restricted cubic splines, ad...