Nutritional redox reprogramming in cardiometabolic diseases: alpha-lipoic acid, urolithin A, and ergothioneine as modulators of the ferroptosis–mitophagy axis and mitochondrial metabolic remodeling (opens in new tab)

Cardiometabolic disorders, encompassing atherosclerosis, myocardial ischemia, and myocardial infarction, persist as predominant contributors to morbidity and mortality on a global scale. An expanding corpus of research delineates redox imbalance, ferroptosis, compromised mitophagy, and mitochondrial metabolic dysfunction as pivotal determinants of cardiovascular pathophysiology. The paradigm of nutritional redox reprogramming has emerged as a potentially effective approach to modulate these i...