The context-dependent roles of PPAR-γ in adipocyte differentiation and obesity: a master regulator with dual functions (opens in new tab)

Obesity has become a global public health crisis. It is characterized by pathological proliferation of adipose tissue resulting from an energy metabolism imbalance. Adipocyte differentiation is the core process driving this proliferation and is tightly regulated by a complex molecular network. Peroxisome proliferator-activated receptor gamma (PPAR-γ) is the primary regulator of adipocyte differentiation. It also plays a key regulatory role in lipid and glucose metabolism as well as inflammato...