Functional processing enhances hepatic targeting: the OAT2/MRP2 mechanism of vinegar-processed Cyperi Rhizoma (opens in new tab)

Processing techniques play a critical role in modifying the bioavailability of botanical ingredients. Traditional processing theory suggests that vinegar processing enhances the hepatic-targeting effects of Cyperi Rhizoma (CR), a botanical used in functional foods and traditional medicine. However, the molecular mechanism remains largely unexplored. This study integrated in silico docking with in vitro experiments to investigate vinegar processing on hepatic uptake of CR bioactive components....