Simulating the biochemical environment for infant intestinal digestion: key challenges and recommendations (opens in new tab)

Digestion in the small intestine is a crucial step in the breakdown and absorption of nutrients from human milk. In vitro models of intestinal digestion are commonly employed to investigate the digestion behaviour of breast milk nutrients. Accurate replication of the infant small intestine requires a detailed understanding of its biochemical environment. This review summarises current knowledge on small intestinal digestion in infants, integrating evidence from both human studies and in vitro...