Insights into the effects of gut microbiota and circulating metabolites on oral cancer: Mendelian randomization analysis and clinical validation (opens in new tab)

BackgroundPrior studies have indicated that alterations in the gut microbiota could potentially influence the occurrence of oral cancer. However, the causal relationship between gut microbiota and oral cancer, as well as whether circulating metabolites serve as mediators, remains unclear.MethodsWe employed bidirectional two-sample Mendelian randomization (MR) to explore the causal relationships between gut microbiota, circulating metabolites, and oral cancer. The inverse-variance weighting MR...