Natural product FZJDXJ enhances CD8+ T-cell glycolysis to relieve exhaustion and augment antitumor immunity in HBV+ hepatocellular carcinoma (opens in new tab)

ObjectiveTo investigate whether Fuzheng Jiedu Xiaoji Formula (FZJDXJ) reverses immunosuppression in HBV? hepatocellular carcinoma (HCC) by reprogramming CD8? T-cell glycolysis and enhance antitumor immunity.MethodsA translational study was conducted with 80 HBV? HCC patients, Hepa1-6 tumor-bearing mouse models and in vitro CD8? T-cell assays. Flow cytometry, GC/LC-MS metabolomics, Western blot and functional experiments were used to detect CD8? T-cell immunophenotype, glycolytic metabolism an...