Heat-processed rodent chow alters nutritive content and improves metabolic outcomes in insulin-resistant female mice (opens in new tab)

IntroductionAnimal research diets are often autoclaved for sterilization. Autoclaved chow can also serve as a model for investigating the health effects of heat-processed foods. Emerging evidence finds that heat-processed foods adversely affect human health. We hypothesized that autoclaved chow would further impair metabolism in a mouse model of androgen-induced insulin resistance.MethodsC57BL/6J mouse breeding pairs were exposed to an autoclaved chow diet or a non-autoclaved, nutrient-matche...