Serum BDNF as an Integrative Neuro-Immunometabolic Marker in Adolescent Polycystic Ovary Syndrome (PCOS): Divergent Dietary and Inflammatory Associations Across Weight Phenotypes (opens in new tab)

BackgroundPolycystic ovary syndrome (PCOS) in adolescence is characterized by hormonal imbalance, low-grade inflammation, oxidative stress, and metabolic dysfunction. Brain-derived neurotrophic factor (BDNF) regulates energy homeostasis and neuroimmune signaling and may act as a neuroimmunometabolic integrator in PCOS.MethodsForty adolescent females with PCOS (26 normal weight and 14 with overweight and obesity) were evaluated. Serum BDNF, omega-3 fatty acids (EPA, DHA), uric acid, metabolic ...