Multimodal MRI local metrics and cognitive performance following water intake in 12-h water-restricted adults: a randomized controlled trial (opens in new tab)

Background and ObjectiveHydration fluctuations affect brain structure, function, and cognition, but underlying neurobiological mechanisms remain unclear. This RCT investigated dose-dependent effects of water intake on multimodal MRI metrics and cognitive performance in young adults after 12-h water restriction.Methods64 healthy university students (18–23 years) underwent 12-h water restriction and were randomized to high (500 mL), medium (200 mL), low (100 mL) water intake, or control (no wat...