Early versus delayed enteral nutrition in septic shock: a target trial emulation study (opens in new tab)

BackgroundThe optimal timing of enteral nutrition (EN) initiation in septic shock remains uncertain. Although early EN is recommended for critically ill patients in current guidelines, evidence specific to septic shock is limited and inconsistent. Observational studies evaluating treatment timing are also vulnerable to immortal time bias and time-dependent confounding. Target trial emulation offers a structured approach to estimating trial-like effects from observational data while reducing t...