Relationship between single point insulin sensitivity estimator index and nonalcoholic fatty liver disease in Chinese middle-aged and older adults: a cross-sectional study (opens in new tab)

BackgroundNonalcoholic fatty liver disease (NAFLD) is a major public health issue, especially in China’s middle-aged and elderly population. Insulin resistance (IR) is a key pathogenic factor, yet its gold-standard assessment methods are complex and invasive, limiting clinical use. The Single Point Insulin Sensitivity Estimator (SPISE) index—based on routine measures such as body mass index (BMI), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C)—offers a simple, insulin-fr...