Ergothioneine-rich water extracts of Hericium erinaceus HE-17 alleviate Alzheimer's disease in mice by regulating oxidative stress, inflammation, and the gut microenvironment (opens in new tab)

Alzheimer’s disease (AD) imposes a significant global disease burden, necessitating simple dietary interventions to prevent or delay disease progression. However, the neuroprotective effects of ergothioneine (EGT)-rich natural extracts as dietary supplements remain largely unexplored. This study aimed to screen a high EGT-producing Hericium erinaceus strain (HE-17) from 29 isolates, optimize its culture conditions and amino acid supplementation using single-factor and orthogonal experiments, ...