Methionine restriction improves lipid metabolism disorders and enhances immunity in obese mice through liver lipid remodeling (opens in new tab)

BackgroundMethionine-restriction diet (MRD) has been reported to improve obesity-related metabolic disorders, but its effects during weight loss and the underlying mechanisms remain unclear. This study investigated whether reducing dietary methionine could improve metabolic status, reshape lipid composition, and influence inflammatory and antibacterial responses in high-fat diet (HFD) induced obese mice.MethodsMale C57BL/6 mice were fed a high-fat diet for 16 weeks to induce obesity and were ...