Folate deficiency correlates with severity of primary biliary cholangitis via modulating key regulatory genes (opens in new tab)

ObjectiveTo investigate the association between serum folate and Primary biliary cholangitis (PBC) progression through clinical, transcriptomic, and protein-level analyses.MethodsSerum folate levels were measured in 90 patients with PBC and 90 healthy controls. RNA-sequencing (RNA-seq) was performed on three subgroups (PBC patients with normal folate, PBC patients with low folate, and controls), and six candidate genes were validated by enzyme-linked immunosorbent assay (ELISA).ResultsSerum f...