Hongjam, an edible silkworm-derived food, attenuates steatohepatitis and fibrosis via multi-axis modulation of metabolic stress, inflammation, and fibrogenic signaling (opens in new tab)

IntroductionMetabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disease characterized by sustained inflammation and fibrosis, for which effective disease-modifying therapies remain limited. In this study, we investigated the hepatoprotective effects of Hongjam, a processed edible silkworm-derived food, in a methionine-choline-deficient (MCD) diet-induced mouse model of MASH.MethodsHistological analysis, plasma biochemical assessments, western blotting, quantitative ...