Intermittent fasting alleviates ulcerative colitis via lithocholic acid-mediated macrophage reprogramming (opens in new tab)

BackgroundUlcerative colitis (UC) is a relapsing inflammatory disorder, in which nutritional intervention has emerged as a modifiable factor for influencing disease onset and severity. This study aimed to investigate whether intermittent fasting (IF) alleviates UC and identify the underlying mechanisms, focusing on bile acid metabolism-immune system crosstalk.MethodsThe study employed a 5:2 IF intervention (5 days ad libitum eating, 2 days low-calorie intake) in a chronic colitis model. Bile ...