Evaluating the anti-gut dysbiotic potential of bioactive primary metabolites derivatives from Lactaplantibacillus plantarum 12–3. An integrated ADMET, network pharmacology, molecular docking and normal mode analysis approaches (opens in new tab)

IntroductionIntestinal dysbiosis is a disorder of the gut microbiome, characterized by a loss of equilibrium between the microorganisms found in the gastrointestinal tract and their hosts. It leads to metabolic changes in both the gut and in the body’s inflammatory response, and adversely affects the epithelial cells that line the intestines. This article aimed to study the mechanisms whereby three metabolites, produced from Lactiplantibacillus plantarum, including 2,4-decadienal, (Z)-ethyl h...