Resistant starch selectively depletes a putative pathobiont-enriched gut microbial module: evidence from multiple dietary fiber intervention cohorts (opens in new tab)

ObjectivesDietary fiber, particularly resistant starch (RS), has been proposed to modulate the gut microbiota and immune microenvironment; however, individual intervention studies yield inconsistent results due to inter-study heterogeneity. This study aimed to identify reproducible gut microbiota responses to RS across multiple independent cohorts and explore the ecological basis by which RS shapes microbial community structure.MethodsGut microbiota composition was analyzed in 586 paired feca...