Aggregation-induced stabilization of pheophorbide, a water-soluble chlorophyll derivative (opens in new tab)

BackgroundChlorophyll (Chl) is a valuable natural pigment, but its application is limited by poor water solubility and photoinstability. This study focuses on the preparation of pheophorbide (Phide), a water-soluble chlorophyll derivative, and investigates the possible role of molecular aggregation in enhancing its photostability.MethodsPhide was synthesized from Spirulina-derived chlorophyll through saponification. Structural characteristics were analyzed using Fourier Transform Infrared (FT...