Dietary L-arginine supplementation exerts preventive effects on colitis through modulation of the gut microbiota (opens in new tab)

BackgroundUlcerative colitis (UC) is a chronic, relapsing gastrointestinal disease that imposes an increasing global health burden. Our previous study showed that L-arginine (Arg) could markedly alleviate experimental colitis; however, the relative efficacy of its prophylactic versus therapeutic intervention remains unclear, and the underlying mechanisms require further elucidation.MethodsMice received Arg supplementation either prior to DSS exposure (BeArg) or during DSS treatment (DuArg). I...